Gender differences in influence of prenatal photoperiods on postnatal pineal melatonin rhythms and serum prolactin and follicle-stimulating hormone in the Siberian hamster (Phodopus sungorus).

Abstract

In Siberian hamsters, the rate of testicular maturation during juvenile life can be influenced by both the prenatal photoperiod and the day length experienced postnatally. In this report, potential postnatal photoperiodic mechanisms modified by prenatal photoperiod were investigated in this species. The study examined the effect of prenatal photoperiodic history on the postnatal pineal melatonin (MEL) rhythm and on postnatal secretion of FSH and PRL. In the first study, the pineal MEL content of hamsters, gestated in either 16 h of light and 8 h of darkness/day (16L) or 10L and raised postnatally in 14L, was monitored at various times of the day and night at 18 days of age. We found that prenatal photoperiod did influence the postnatal pineal MEL rhythm in 18-day-old males, but a similar effect was not evident in females. For males, the durations of the nocturnal elevation of pineal MEL were 8.5 and 7 h in 16L and 10L gestated hamsters, respectively. However, MEL rhythms were similar to each other in the corresponding groups of females (8.5- and 9-h durations of elevated pineal MEL in 16L and 10L prenatal photoperiod groups, respectively). In a subsequent study using the same photoperiod paradigm, FSH and PRL concentrations were examined in both genders at 3- to 10-day intervals between 18-62 days of age. The serum PRL (day 22) and FSH (days 18 and 22) concentrations in males were significantly affected by prenatal photoperiod. Specifically, circulating serum PRL (on day 22) and FSH (on days 18 and 22) concentrations were increased substantially in 10L gestated, compared to 16L gestated, males raised in 14L after birth. In contrast, serum FSH concentrations in female hamsters were not different between 16L and 10L gestated groups at these times. In another study using the same experimental design, the pattern of testicular development was explored in males. Hamsters that had experienced a 10L photoperiod prenatally and were raised in 14L exhibited rapid testicular growth from 27-52 days of age compared to hamsters that had experienced a 16L prenatal photoperiod and were reared in 14L. These results support the hypothesis that in juvenile male hamsters exposed to 14L postnatally, endogenous MEL production and serum FSH concentrations are influenced by photoperiodic information received during fetal life. In addition, these findings help to explain why males gestated in 10L and raised in 14L exhibit accelerated testicular development in the first 2 months of life compared to males gestated in 16L and transferred to 14L after birth.(ABSTRACT TRUNCATED AT 400 WORDS)