Abstract
Angiogenesis and vasculogenesis are two very important processes in the development and maintenance of mammalian health. In sled dogs, the angiogenic role is to supply and support tissue with ample vasculature, thus providing a route of access for the transportation of essential nutrients, including oxygen and the removal of waste in a sustained fashion. VEGF has been shown to be a key mediating factor in the underlying cascade of chemical events leading to angiogenesis, which makes it a very important precursor molecule for both muscle development and early neoplasia detection. The overall purpose of this study was to establish circulatory baseline VEGF levels in healthy dogs to develop an alternative mammalian model. Mean VEGF levels were 19 pg mL‾1 in sled dogs (n=20) and 5 pg mL‾1 in beagles (n=4). There were significant baseline VEGF-ir differences between male and female dogs and exercising males and exercising females. In addition preliminary data on beagles suggest that breed may play a role in baseline VEGF-ir levels. This study is the first step in the biotechnological development of a diagnostic VEGF assay in dogs.
Highlights
Angiogenesis is a major process in the development and maintenance of mammalian health
Folkman proposed that if specific proteins existed, those proteins could help in the elucidation of angiogenic abnormalities
All dogs tested were immunoreactive for vascular endothelial growth factor (VEGF)-ir in their plasma (Table 2)
Summary
Angiogenesis is a major process in the development and maintenance of mammalian health. There are many stimulators which can initiate angiogenesis Most of these stimulators are specific proteins called growth factors. Folkman proposed that if specific proteins existed, those proteins could help in the elucidation of angiogenic abnormalities. It was not until 1984 that the first of these specific angiogenic proteins was isolated and characterized[3]. Many angiogenic genes and gene products have been isolated, purified and characterized These angiogenic stimulatory molecules (ASM) can be divided into seven major groups: 1, growth factors; 2, proteases; 3, trace elements or metals; 4, oncogenes; 5, cytokines; 6, molecules involved in cellular signal transduction (STMs) and 7, endogenous angiogenic inducers
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: American Journal of Biochemistry and Biotechnology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
