Abstract
The purpose of the present study was to explore the role of gender in the relation of high-sensitivity C-reactive protein (hsCRP), white blood cell (WBC) count, and serum uric acid (UA) to the risk of future cardiovascular disease (CVD) events. In total, 404 workers were recruited to obtain the measurements of serum markers for CVD risk. Demographic data, nutrition, exercise, smoking, and alcohol consumption were assessed through a questionnaire. The Framingham Risk Score (FRS) was adopted to estimate the risk of future CVD events. Multiple linear regression models were used to determine CVD risk markers in relation to the FRS by gender. The hsCRP was not significantly correlated with the FRS for all workers after adjusting for covariates, including demographic data and health-related lifestyle. WBC count was positively correlated with FRS for all workers, but WBC count did not show an interaction with gender with respect to the FRS. Serum UA showed an interaction with gender on the FRS, and UA positively correlated with the FRS in males though not in females. With respect to CVD prevention, the WBC count can be used to monitor the risk for all workers. Due to a gender difference shown in the relationship between serum UA and the FRS, serum UA can be a monitor of the risk of future CVD events in male workers only.
Highlights
Serum uric acid (UA) positively correlated with Framingham Risk Score (FRS) in male workers, but not in female workers; (2) white blood cell (WBC) count positively correlated with FRS for all workers; and (3) highsensitivity C-reactive protein (hsCRP) did not show a significant association with FRS for both genders
The present study suggested that the WBC count should be considered when exploring whether the prediction of the risk of future cardiovascular disease (CVD) events based on hsCRP has preventive applicability
The WBC count can be used to monitor the risk of future CVD events for all workers
Summary
Cardiovascular diseases (CVDs) are the leading causes of mortality worldwide. An estimated 31% of all global deaths were from CVDs in 2016 [1]. Among the 10 leading causes of mortality in Taiwan in 2019, malignant tumor ranked first, followed by cardiovascular-related diseases, including heart disease, cerebrovascular disease, diabetes, and hypertension, ranking second, fourth, fifth, and eighth, respectively [2]. These CVDrelated diseases were the top six causes of death in Taiwanese workers [3].
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