Gender difference in the association of melanoma etiology to solar UV exposure.

Feng Liu-Smith,Frank L Meyskens,Jing Liu,Argyrios Ziogas,Archana Mceligot,Ahmed Farhat,Zi Wang,Thomas H Taylor,Hoda Anton-Culver,Anthony Arce,Vandy Yourk

doi:10.1200/jco.2015.33.15_suppl.e20012

Abstract

e20012 Background: UV radiation has been considered the major environmental causative factor for melanoma. Our previous limited epidemiologic study suggested additional causative factors for early ...

Highlights

Melanoma and non-melanoma skin cancer case and population information were retrieved from various cancer registries and public domains
The current study further compared the age and gender-specific incidence rates for melanoma and non-melanoma skin cancer (NMSC) from the Netherlands (N), UK and Nordic (NOR) countries, and confirmed a peak gender difference at age 20-24 for melanoma in all countries examined( N, RR = 2.40, 95% CI 2.12, 2.72; UK, RR = 2.10, 95% CI: 1.84, 2.38; NOR, RR = 2.14, 95% CI: 2.16, 2.68) which was not observed (N, RR = 0.98, 95% CI: 0.65-1.49; NOR, RR = 1.01, 9%% CI: 0.74, 1.37) or less obvious (UK, RR = 1.36, 95% CI: 1.15, 1.61) in NMSC
We further analyzed the relationship between UV index (UVI) and gender-specific and age-standardized melanoma incidence rates from 14 selected countries and regions, where most populations are Caucasians and have light hair color, and discovered that there was a significant correlation between the male incidence rates and UVI (Pearson’s coefficient r = 0.67, p = 0.009), but only modest and non-significant correlation (r = 0.45, p = 0.109) between the female incidence rates and UVI

Summary

Introduction

Title Gender difference in the association of melanoma etiology to solar UV exposure. Gender difference in the association of melanoma etiology to solar UV exposure.

Results

Conclusion