Abstract
BackgroundAn epidemiological approach to preventing the development or progression of chronic kidney disease (CKD) is necessary, while few effective preventive measures are currently available. We conducted a community-based, cohort study to identify the factors associated with the development of CKD in the general population.MethodsWe examined 1876 local residents of a Japanese community who had an annual health check-up and, of those, 1506 residents judged not to have CKD (473 men and 1033 women) were followed for the development of CKD over 10 years.ResultsThe numbers of male and female residents who developed CKD during the follow-up period were 167 (35.3%) and 299 (28.9%), respectively. As compared to those without CKD development, the residents who developed CKD were older, and had a higher body mass index (BMI), systolic blood pressure, and creatinine in both genders. The rate of CKD development in obese female residents was higher than in non-obese women, but such a difference was not noted in male residents. In addition to age and serum creatinine, we identified BMI as an independently significant factor for the development of CKD in women, but not in men.ConclusionsIncreased BMI is a significant risk factor for the development of CKD in women, and there seems to be a gender difference in the association between increased BMI and the development of CKD in the general population.
Highlights
An epidemiological approach to preventing the development or progression of chronic kidney disease (CKD) is necessary, while few effective preventive measures are currently available
Chronic kidney disease (CKD) has recently been recognized as a challenging public health issue because the number of patients with end-stage renal disease (ESRD) is steadily increasing in developed countries including Japan, and because epidemiological studies have shown that CKD is a significant risk factor for cardiovascular disease [3,4,5]
We followed the local residents of that area, who had been judged not to have CKD, for 10 years to identify the factors associated with future development of CKD in a general population
Summary
An epidemiological approach to preventing the development or progression of chronic kidney disease (CKD) is necessary, while few effective preventive measures are currently available. We conducted a community-based, cohort study to identify the factors associated with the development of CKD in the general population. The number of ESRD patients in Japan is currently some 300,000, and this has become an economic to age, in male and female residents of the Kiyotake area, a Japanese community [17]. We followed the local residents of that area, who had been judged not to have CKD, for 10 years to identify the factors associated with future development of CKD in a general population
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