Abstract
To investigate the hypothesis that differing mRNA levels underlie gender differences in the contractile response of the rat tail artery, α 2-adrenoceptor mRNA was measured using in situ hybridization. Messenger RNA for the α 2A- and α 2C-adrenoceptor subtypes was found localized to the smooth muscle layer. There was no detectable mRNA present for the α 2B-adrenoceptor subtype. Levels of α 2C-adrenoceptor mRNA were greater in female compared to male tail arteries (417±35 vs. 263±38 dpm/mg, P=0.01), while levels of α 2A-adrenoceptor mRNA were the same in both sexes. Levels of α 2-adrenoceptor mRNA may parallel levels of functioning protein present in the rat tail artery.
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