Gender difference in crescentic glomerulonephritis; an eleven-year single-center study

Abstract

Introduction: Crescentic glomerulonephritis is an essential kind of glomerulonephritis. According to its rapid progression and aggressiveness, recognizing its risk factors helps to manage a better treatment and outcome. Objectives: This study was designed to compare demographic, laboratory, and renal biopsy findings of patients with crescentic glomerulonephritis among males and females. Patients and Methods: This cross-sectional study compared age, gender, types of crescentic glomerulonephritis, serum creatinine, 24-hour proteinuria, the number of crescents, and percentage of fibrosis. Results: Of 169 patients with crescentic glomerulonephritis, 54.4% were males, and 45.6% were females. The mean age, serum creatinine level, and 24-hour proteinuria were 37.73±15.32 years, 2.06±1.35 mg/d, and 2084.82±1170.98 mg/d, respectively. Serum creatinine level and 24-hour proteinuria were not significantly different by gender. In addition, the number of crescents had no relationship with age and 24-hour proteinuria; however, it had a significant direct relationship with serum creatinine. Conclusion: According to our study, lupus nephritis affected women more than men, while other forms of crescentic glomerulonephritis were more common in males. Depending on the population, a significant relationship between the number of crescent and serum creatinine was detected. The mean age of females with crescentic glomerulonephritis was significantly lower than males.