Gender difference in coronary artery disease

Abstract

Background: Coronary artery disease (CAD) continues to exert a substantial impact on global health, being the main factor causing morbidity and mortality in North America and Europe. Men and women have different incidences of CAD and risk factors, which has been widely reported across populations. In light of a notable scarcity of studies examining the variation in CAD risk among different subgroups. We investigated how cholesterol, glucose, blood pressure, and age affect CAD risk in different sex and smoking groups. Method: Framingham Heart Study, a longest-running cardiovascular epidemiological investigation used furnishing valuable insights into CAD risk. Investigating the relationship between these characteristics and the occurrence of CHD involved using logistic regression. Result: For blood pressure variable among smoking group, there were significant increase in male group (=0.0255, P<0.001) compared with non-smoking group (=0.0164 in male, =0.0162 among female group, P<0.001) and reduction among female group (=0.0089, P<0.001). Within the female group, the age variable exhibited a notable reduction in smoking group (=0.0460, P=0.0020) compared with the non-smoking group (=0.0829, P<0.001). After adding the interactions between smoking and blood pressure, smoking and age. In the male group, both smoking and the interaction become insignificant, whereas in the female group the interaction is significant. Conclusion: Our study suggested that high level of glucose, total cholesterol and blood pressure increased the risk of CAD. By dividing into subgroup, we discovered that the combined presence of smoking and increased blood pressure, and of smoking and age could potentially exert a more adverse effect on pressure wave reflection in women compared to men.