Gender difference analysis of Xp11.2 translocation renal cell carcinomas\u2019s attack rate: a meta-analysis and systematic review

Wenyuan Zhuang,Weidong Gan,Hongqian Guo,Chunni Zhang,Ning Liu

doi:10.1186/s12894-020-00696-1

Abstract

BackgroundXp11.2 translocation renal cell carcinoma (tRCC) is recently recognized. As Xp11.2 tRCC involved gene translocation and fusion in X chromosome and the number of X chromosomes in female is twice of male, we wondered whether the gender difference of attack rate is consistent with the proportion of the X chromosome. Methods: In the present paper, meta-analysis was performed to find out the difference of morbidity between male and female.ResultsNine studies with 209 cases calculated. Odds ratios (ORs) and ORs with 95% confidence intervals (CIs) were calculated for attack rate of Xp11.2 RCC with different gender. The result showed that the attack rate of female was higher than that of male with pooled OR of 2.84 (95% CI = 1.48–5.45), while the rate rises even further in adult (OR = 3.37, 95% CI =2.19–5.18). In other types of common kidney cancer, the OR value is less than 1, which means that the incidence of female is lower than that of male.ConclusionsThe result showed that the incidence rate of female patients is much higher than that of male patients with Xp11.2 tRCC, it was reasonable to indicate that this particular incidence rate is related to the X chromosome.

Highlights

Xp11.2 translocation renal cell carcinoma is recently recognized
The functional domain of the Transcription factor binding to IGHM enhancer 3 (TFE3) gene fused with the promoter of other genes, housekeeping gene usually, resulting to the TFE3 protein is constitutively overexpressed in Xp11.2 translocation renal cell carcinoma (tRCC) which can be identified by IHC [4, 5]
Gender-related incidence of all included studies of Xp11.2 tRCC A total of 209 cases with 131 women and 78 men were included

Summary

Introduction

Xp11.2 translocation renal cell carcinoma (tRCC) is recently recognized. As Xp11.2 tRCC involved gene translocation and fusion in X chromosome and the number of X chromosomes in female is twice of male, we wondered whether the gender difference of attack rate is consistent with the proportion of the X chromosome. Xp11.2 translocation renal cell carcinoma (tRCC) was delineated as a distinct entity in the 2004 World Health Organization (WHO) renal tumor classification [1]. A total of 5 Xp11.2 tRCCs have been identified in RCC tumors, PRCC-TFE3, ASPSCR1-TFE3, SFPQ-TFE3, NONO-TFE3, and CLTC-TFE3, all of which result in TFE3 (transcription factor binding to IGHM enhancer 3) gene fusions [3]. Several published studies showed the female predominance in incidence of Xp11.2 tRCC while a few studies reported it is seen more often in males than in females [1]

Methods

Results

Discussion

Conclusion