Abstract
Objective: Today there is a limited number of gender-based characteristics of the enalapril and losartanadministration in order to correct blood pressure in patients with arterial hypertension.The aim ofthe study was to compare the effectiveness of enalapril and losartan for blood pressure correcting inpatients with arterial hypertension (AH), depending on gender.
 Materials and methods: The studywas carried out in 2019 at Military Hospital 175 in Ho Chi Minh city, Vietnam. To achieve this goal,100 people were included in the study (50 females in the menopause and 50 males) with grade I-IIarterial hypertension aged 50 to 60 years. Patients with hypertension were divided into the followinggroups: group 1A – 25 males, who received enalapril 20 mg/d and 12.5 mg/d hydrochlorothiazideonce per day as antihypertensive therapy; group 1B – 25 males, who received losartan 50 mg/d andhydrochlorothiazide 12.5 mg/d once per day; group 2A – 25 females, who received enalapril 20 mg/dand hydrochlorothiazide 12.5 mg/d once per day; group 2B – 25 females, who received losartan 50mg/d and hydrochlorothiazide 12.5 mg/d once per day. The follow-up was 12 weeks.
 Results anddiscussion: The study showed that antihypertensive therapy with losartan is more effective in femalescompared with enalapril, as evidenced by a significant SBP decrease by 21.1% (p<0.05) at the endof treatment with losartan in females versus 18.6% (p<0.05) when using enalapril with the presenceof a statistically significant intergroup difference in the indicator (p<0.05).
 Conclusion: Our resultsindicate the presence of a gender difference in the antihypertensive effect of losartan and enalapril.
 Bangladesh Journal of Medical Science Vol.20(2) 2021 p.348-355
Highlights
Despite the achievements of modern medical science, arterial hypertension (AH) is still the most common chronic disease in the world[1,2,3,4,5]
Losartan is more effective for controlling blood pressure in females than in males, which is confirmed by the presence of a statistically significant difference (p
In Sweden, a large-scale study, which included 292,428 individuals aged 20+ (average age was (63.0 ± 13.0) years, females’ ratio in the study 53%), established that females with hypertension were more often treated with angiotensin receptor blockers (ARBs) and diuretics, which were more effective for this gender in relation to the correction of blood pressure, and males with angiotensin converting enzyme (ACE) inhibitors and calcium channel blockers (CCBs)[24]
Summary
Despite the achievements of modern medical science, arterial hypertension (AH) is still the most common chronic disease in the world[1,2,3,4,5]. Adverse cardiovascular events in females occur at a later age and with a lower frequency 13 This was demonstrated in a study conducted by Boggia et al, which included 9357 people (average age 52.8 years, 47% of the examined were females) who underwent 24-hour blood pressure monitoring. Materials and methods: The study was carried out in 2019at Military Hospital 175 in Ho Chi Minh city, Vietnam To achieve this goal, 100 people were included in our study (50 of them were females in menopause and 50 males) with grade I-II arterial hypertension (AH) between the ages of 50 and 60, as well as 25 healthy individuals (HI). In order to determine the left ventricle ejection fraction (LVEF), to stratify the risk and assess diastolic LV function, echocardiography was
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