Gender association of impulse control disorders (ICD-RBS) in patients with Parkinson's disease and its impact on quality of life

Abstract

ICD-RBs are under-recognized in clinical practice as patients do not spontaneously offer information, either because of shame or they do not understand its correlation to PD and its treatment. Certain ICD relevant in the Indian scenario apart from the criteria set in QUIP-RS have not been studied yet were explored. To study the gender difference and risk factors in the prevalence of ICD-RBs in Indian PD patients and its impact on Quality of life(QOL). Hospital based observational cross-sectional study of PD patients on treatment with dopamine replacement therapy for more than six months visiting movement disorder clinic. After informed consent, patients or informant completed the QUIP-RS questionnaire, in the language of choice (English/Punjabi/Hindi) based on behavior that occurred anytime during PD and lasted >4 consecutive weeks. In addition other ICDs relevant in the Indian population as body-focused repetitive behaviors were also explored as a new part of the QUIP-RS questionnaire. The frequency and impact of ICD on QOL was studied using validated PDQ-39 Questionnaire. 1.Total 80 patients (46 men,34 women) were included in 6 months period.2.Trends show ICD-RBs are more frequent in women (41.8%)compared to men(32%) with punding being the most frequent(Fig. 1).3.At least one ICD-RB was present in 31(38.74%) patients Table 1.4.‘ICD not classified elsewhere’ as trichotillomania was present in 3(3.75%) patients.5.Significant risk factors for ICD-RB are younger age, longer disease, more years of treatment and higher dose of dopamine.6.QOL was much worse in those with any ICD-RB than those without any ICD-RB(Table 2).