Abstract
The effect of ACTH on retention of Pavlovian fear conditioning was investigated in weanling rats. No influence of ACTH on memory was observed in male and female pups of primiparous dams. Male offspring of multiparous dams displayed increased retention with the ACTH reactivation treatment, as indexed by three behavioral measures. Female offspring of multiparous dams, as well as those of primiparous dams, demonstrated linear ACTH dose-dependent increases in vacillatory activity, but no facilitation of memory. Collectively, the present data extend the generality of ACTH-induced memory reactivation to include the attenuation of infantile amnesia, but also suggest that this effect is constrained by gender of the offspring and maternal parity.
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