Abstract
AbstractDifferent epidemiological studies demonstrated that male gender and age are risk factors for the progression of liver disease. Regarding age, it has been associated with liver mass and blood flow reduction, whereas in gender, the estradiol has revealed protective roles in models of liver fibrosis and of trauma-hemorrhage in rats. So far, most of the studies on aging focused their attention in hepatocyte (HEP) structure and function and few data exists pertaining to other liver cell subpopulations, including hepatic stellate cells (HSC) and Kupffer cells (KC). To the best of our knowledge, an integrative analysis (with modern stereology) of the liver cell populations, throughout aging and gender, has never been performed.
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