Abstract
Vaccination has been a key protective behavior for COVID-19. This study investigated the clinical status of university professors administered the Vaxzevria COVID-19 vaccine, to monitor for any adverse reaction, and to understand attitude and hesitancy to vaccination. Data were collected through an online survey. The study received approval from the relevant ethics committee “Comitato Etico Campania Sud”. Multivariate logistic regressions were used to calculate significant predictors of the outcomes of interest. A gender and AB0 blood type difference in adverse vaccine reactions was found. The multivariate logistic regression model showed that female gender, city residence, blood type A+ and B−, and chronic underlying medical conditions or comorbidities were more strongly implicated in the occurrence of adverse reactions, whereas blood type 0 Rh+ or blood type A Rh− were protective factors of adverse reactions to the Vaxzevria vaccine. Both genders did not show serious adverse reactions to the Vaxzevria vaccine. Based on our results, we are able to support the hypothesis that AB0 blood type and gender difference appear as predictors of Vaxzevria COVID-19 vaccine reactogenicity. Furthermore, in the study population, the degree of concern and hesitation to undergo vaccination was minimal.
Highlights
The world has been overwhelmed by one of the most widespread and significant public health crises of recent decades due to a new coronavirus disease 2019 (COVID-19)causing severe acute respiratory syndrome (SARS-CoV-2)
Numerous were females belonging to blood type A Rh± (27.7%) and B Rh± (34.1%)
The main objectives of this study were to investigate the clinical status of university professors, who were subjected to the Vaxzevria COVID-19 vaccine, and to understand whether there was a relationship between adverse reactions to the vaccine and the predictive factors considered
Summary
The world has been overwhelmed by one of the most widespread and significant public health crises of recent decades due to a new coronavirus disease 2019 (COVID-19)causing severe acute respiratory syndrome (SARS-CoV-2). Two years into the pandemic, the coronavirus is responsible for more than five and a half million confirmed deaths worldwide (as of 15 February 2022), according to John. The second nation after Wuhan, China to be hit hard at the start of the pandemic, as of 15 February 2022 reported 12.1 million confirmed cases and 151,000 deaths nationwide [3]. Vaccination has been a key protective behavior for COVID-19 [8], and played an important role in increasing population immunity, preventing serious disease, and reducing the health crisis [9]. The rate of confirmed deaths appears to have slowed since the world reached four million vaccines in early July [10]. According to national surveillance data from the first 4 months of the vaccination campaign in Israel, two doses of the COVID-19 vaccine reduced both symptomatic and asymptomatic infections, hospitalizations, serious illness and deaths [11,12]. Several studies have shown cases of adverse reactions such as thrombosis in connection with thrombocytopenia after
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