Abstract
As drug carriers of nanomaterials, especially those capable of generating stimulatory responses, they can change the mechanism of drug metabolism and improve drug utilization. In this paper, a drug-loaded porous silica composite with a pH-responsive type was prepared. This composite was prepared by using three-dimensional caged silica (SBA-16) as the carrier, 3-aminopropyltriethoxysilane (APS) as the silane coupling agent, and indomethacin (IMC) as the drug loading center, respectively. The drug-loaded precursor NH2-SBA-16@IMC was prepared by solution diffusion adsorption. Finally, the pH-responsive drug-loaded composite NH2-SBA-16@IMC@GA was synthesized by wrapping the NH2-SBA-16@IMC with a condensation polymer of gelatin and glutaraldehyde. The loading of IMC into the aminopropyl-modified SBA-16 cage pores was demonstrated by various characterization techniques. The in vitro simulated release performance of the drug-loaded composite was investigated at 37 °C under three pH conditions. The results show that the NH2-SBA-16@IMC@GA can be released in response to the pH environment of the colon, which can effectively control the release speed of the drug indomethacin.
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