Abstract
In the present study, a different approach for the preparation of poly(ethylene glycol) diacrylate-gelatin (PEGDA-gelatin) hydrogels was investigated. Gelatin type A from porcine skin was used as the co-initiator of a radical photo-initiating system instead of the traditional aliphatic or aromatic amines. This became possible because, upon visible-light irradiation, the amine sequences within gelatin generate initiating free-radicals through the intermolecular proton transfer in a Norrish type II reaction with camphorquinone (CQ). PEGDA-gelatin hydrogels were prepared by visible-light-induced photopolymerization. The gelatin content in the precursor formulations was varied. The influence of gelatin on the kinetics of the photocuring reaction was investigated, and it was found that gelatin fastened the rate of polymerization at all concentrations. The covalent attachment of gelatin segments within the cross-linked hydrogels was evaluated by means of attenuated total reflectance-infrared spectroscopy (ATR-FTIR) spectroscopy after solvent extraction. The thermo-mechanical properties, as well as the swelling behavior and gel content, were also investigated.
Highlights
Hydrogels are three-dimensional polymeric networks that are able to absorb and retain large amounts of water without dissolving [1,2,3]. Due to their water content and tunable physico-chemical properties, they have been increasingly used in tissue engineering (TE) to mimic soft human tissues, and they have been proposed as scaffold materials in regenerative medicine to allow for cell attachment, growth and differentiation [4,5,6]. Both synthetic and natural polymers have been proposed as precursors for the production of hydrogels; while synthetic materials enable a greater control over chemical composition, gel behavior and mechanical properties, natural materials are preferable for their biocompatibility [7]
We investigated a different approach for the fabrication of photocurable poly(ethylene poly(ethylene glycol)diacrylate (PEGDA) hydrogels, an approach that incorporates unmodified glycol)diacrylate (PEGDA) hydrogels, an approach that incorporates unmodified gelatin type A from gelatin from the porcine skin within the cross-linked network, gelatininitself as the porcinetype skinA
The influence of gelatin on the kinetics of PEGDA photopolymerization was evaluated by the means of photorheology
Summary
Hydrogels are three-dimensional polymeric networks that are able to absorb and retain large amounts of water without dissolving [1,2,3] Due to their water content and tunable physico-chemical properties, they have been increasingly used in tissue engineering (TE) to mimic soft human tissues, and they have been proposed as scaffold materials in regenerative medicine to allow for cell attachment, growth and differentiation [4,5,6]. The key steps of free-radical photogeneration generation of efficient photo-initiating systems [22,23,24]. We investigated the use of gelatin as the electron/proton donor species of the photoinitiating system instead of the traditional amines. The thermo-mechanical performance, swelling behavior, and gel content of the resulting hydrogels were studied
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