Abstract
The field of biomaterials has been steadily expanding as a large number of pharmaceutical and manufacturing companies invest in research in order to commercialize biomaterial products. Various three-dimensional biomaterials have been explored including film, hydrogel, sponge, microspheres etc., depending on different applications. Thus, gelatin and polyvinyl alcohol (PVA) are widely used as a natural- and synthetic-based biomaterial, respectively, for tissue engineering and clinical settings. The combination of these materials has proven its synergistic effects in wound-healing applications. Therefore, this review aims to highlight the hybrid gelatin and PVA thin film development and evaluate its potential characteristics for tissue engineering applications from existing published evidence (within year 2010–2020). The primary key factor for polymers mixing technology might improve the quality and the efficacy of the intended polymers. This review provides a concise overview of the current knowledge for hybrid gelatin and PVA with the method of fabricating and mixing technology into thin films. Additionally, the findings guided to an optimal fabrication method and scrutinised characterisation parameters of fabricated gelatin-PVA thin film. In conclusion, hybrid gelatin-PVA thin film has higher potential as a treatment for various biomedical and clinical applications.
Highlights
IntroductionThe tissue engineering (TE) field is an advanced research discipline primarily focusing on producing tissues and organ replacements by regulating cellular and biomechanical parameters in the laboratory
This review has established that gelatin-polyvinyl alcohol (PVA) thin film is one of the biomaterial products that can be beneficial in tissue engineering (TE) and medical applications due to its potentials
It is the easiest method of fabrication and price-considerable materials
Summary
The tissue engineering (TE) field is an advanced research discipline primarily focusing on producing tissues and organ replacements by regulating cellular and biomechanical parameters in the laboratory. TE triad includes the cells as a tissue-building unit whereby bioscaffold acts as a platform for the cells to grow creating solid tissue form and the biomolecules component act as enhancer or supplement. The exponential development of biomaterial technology has revolutionised its use in the biological and industrial fields over the past few decades [1]. Given their widely used applications as bioequivalent materials, polymer blends are very significant and belong to a rapidly advanced branch of polymer science and technology as well as medical applications. In the interests of the quality of patient care and medical research, this will revolutionise medicine towards the various field of drug delivery, drug resistance, gene therapy, diagnostics, medical therapies, treatment protocols, immunomodulators or simulants therapy, surgical interventions and related research areas [3]
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