Abstract
One of the major challenges for the treatment of osteoarthritis (OA) with therapeutic drugs is the short half-life of drugs in the joint cavity. The severity of OA often fluctuates with time and inflammatory factors. Here, we describe the use of a hydrogel material, named Gel-Man, to solve the problem of rapid release of drugs. Gel-Man could encapsulate a series of therapeutic drugs and be degraded by hydrogen peroxide. It could be decomposed, and release drugs controlled by the concentration of hydrogen peroxide in the arthritic joint cavity. This hydrogel loaded with triamcinolone acetonide (TA) could slowly release the drug upon exposure to hydrogen peroxide in the joint cavity in patients suffering from osteoarthritis. The combination of TA and GEL-MAN hydrogels can slowdown the progression of degenerative change of osteoarthritis by maximizing the therapeutic efficacy and prolong the duration of drug treatment.
Highlights
Osteoarthritis is the most common form of arthritis affecting approximately 237 million people (March et al, 2014; Disease et al, 2016)
The drug-loaded hydrogel was incubated in phosphate buffer saline (PBS) with or without adding an appropriate amount of hydrogen peroxide to simulate the joint cavity environment
It is worth noted that the release of triamcinolone acetonide (TA) increased under hydrogen peroxide conditions compared to PBS (Figure 1D)
Summary
Osteoarthritis is the most common form of arthritis affecting approximately 237 million people (March et al, 2014; Disease et al, 2016). It is a chronic orthopedic disease caused by hyperostosis and articular cartilage degeneration. The most common one GEL-MAN Hydrogel for Osteoarthritis Treatment is the intra-articular injection of drugs, such as sodium hyaluronate, medical ozone, chondroitin sulfate, and proprietary Chinese medicine. The advantage of intra-articular injection is that, drugs directly reach the affected joints and high concentration of drugs in the joint cavity, which lowers the systemic side effects. The extraction of the joint fluid can relieve the pressure of the joint and alleviate the symptoms of arthritis
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