Abstract
The author examined the haptoglobin (Hp) type of Japanese by means of Smithies' zone electrophoresis in starch gel. The results are as follows:1) In 232 normal adults, 24 showed Hp 1-1 type, 87 Hp 2-1 type and 121 Hp 2-2 type. The gene frequencies are calculated to be Hp1: 0.291 and Hp2: 0.709. The Hp1 frequency of Caucasian and African races previously reported is not lower than one of the Japanese encountered in this study.2) No relation is revealed between the Hp types and the sex, pregnancy, ABO or Rh blood types and serum protein concentration.3) No determinable Hp pattern is detected in cord bloods or bloods of newborn within 5 days of birth.4) By transfusions of the plasma of different Hp types no causal reaction seems to be provoked. In massive transfusions Hp patterns of recipients are influenced by donors' Hp types and show the Hp patterns like those given by the mixed sera in vitro. The modified patterns disappear in about 2 days. The relative rapid disappearance of transfused Hp may be chiefly due to increased haemolysis in vivo.
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