Gefitinib salts/cocrystals with phenolic acids as a promising solid-state approach to improve solubility

Abstract

In this study, we designed and synthesized a series of gefitinib (GEF) salts and cocrystals with phenolic acids, comprising two salts, one cocrystal, and two salt cocrystals. All these forms exhibited significant improvements in solubility compared to pure GEF.