Gefapixant for chronic cough

Abstract

Chronic cough is responsible for a decrease in quality of life. Chronic cough affects approximately 5–10% of the global population1,2 and might be complicated by incontinence, cough syncope, and dysphonia, leading to social embarrassment and subsequent social isolation and depression or anxiety.3,4 In some people, cough is associated with a treatable underlying disease such as allergic rhinitis, asthma, or gastro-oesophageal reflux disease. Many of these individuals might respond to treatments targeting the primary cause.