Gebelerde İlk Trimester Plazma D Vitamini Düzeyleri ile Gestasyonel Diyabet Arasında İlişki Var mı?

Abstract

Aim: Carried out in pregnant women who had oral glucose tolerance test (OGTT) in two centers in the Western Black Sea Region, this study aims to investigate the relationship of the first trimester plasma vitamin D levels between the groups with and without gestational diabetes mellitus (GDM). Material and Methods: Between the dates of 17.09.2014-15.01.2018 at Bartin State Hospital and Zonguldak Bulent Ecevit University Faculty of Medicine, Department of Obstetrics and Gynecology, 136 pregnant women aged between 18-40 with a single pregnancy who took OGTT and whose vitamin D levels in maternal plasma were examined in their first trimester were included in the study, and the collected data were reviewed retrospectively. Pregnant women who had additional systemic diseases such as pre-pregnancy diabetes, or those with multiple pregnancies, or the ones who did not want to have a glucose screening test, who had not their vitamin D level tested in the first trimester, who were taking vitamin D supplements at the time of admission were not included in the study. The GDM Group of 52 pregnant women who were diagnosed with GDM were matched with the other 84 pregnant women who formed the control group according to the age, gravida, parity, hemoglobin value and body mass index (BMI) at the time of the OGTT test. Results: Both groups were similar in terms of age, gravida, parity, hemoglobin and BMI values (p> 0.05). Considering vitamin D levels, it was found that the level of maternal vitamin D in the first trimester was significantly lower in the group that developed GDM when compared to the group that did not develop GDM (p=0.031). Conclusion: Vitamin D has also been shown to play a role in the pathogenesis of diabetes. In addition, as seen in the few previous studies in the literature, vitamin D deficiency in pregnant women with GDM is found in our regional study, as well. This study, which includes the Western Black Sea Region, will guide more comprehensive prospective studies.