Abstract
Neurosyphilis is a form of tertiary syphilis infection caused by the spirochete bacterium Treponema Pallidum. Frequent use of antibiotics has altered the natural course of syphilis and late-stage neurosyphilis has begun to be seen in different clinical forms. Neurosyphilis may present with neuropsychiatric symptoms and may mimic virtually any psychiatric disorder like psychosis, delirium, personality changes and mood disorders. Here, we present two patients investigated for syphilis serology because of late-onset psychiatric illness with predominant mood symptoms. The first case was diagnosed as “confirmed” neurosyphilis and the second case as “presumptive” neurosyphilis. They were given Penicillin treatment and marked improvement in clinical picture was observed. This report shows the importance of neurosyphilis in the differential diagnosis of late onset psychiatric disorders and atypical clinical presentations
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