Gd2O3, SiO2-Gd2O3 and SiO2-MnO2 nanoparticles as potential MRI contrast agents

A.V Myshkina,O.A Zlygosteva,I.V Byzov,V.V Kasyanova,I.N Bazhukova,V.G Ilves,S.Y Sokovnin

doi:10.1088/1742-6596/1461/1/012111

A.V Myshkina, O.A Zlygosteva + Show 5 more

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https://doi.org/10.1088/1742-6596/1461/1/012111

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Abstract

Gd2O3, SiO2-Gd2O3 and SiO2-MnO2 nanoparticles were produced by the method of pulsed electron evaporation of oxide targets with condensation of the vapors in a vacuum. These materials are considered as probable contrast agents for magnetic resonance imaging (MRI). The Gd2O3 nanoparticles exhibit a rather high r1 and r2 relaxivities. These results point to the potential of using nanocrystals for MRI diagnosis. The mesoporous nanostructures SiO2-Gd2O3 and SiO2-MnO2 could be considered as multimodal theranostic agents.

Highlights

In recent years magnetic resonance imaging (MRI) has become one of the leading research methods and its diagnostic capabilities continue to expand
The purpose of this work is to study the relaxation of gadolinium oxide Gd2O3 nanoparticles, mesoporous nanostructures SiO2-Gd2O3 and SiO2-MnO2 synthesized by gas-phase evaporation of ceramic targets by electron beam, as well as to assess the possibility of their use as MRI contrast agents
Gadolinium oxide nanoparticles Gd2O3 with PEG 2000 stabilizer rather quickly settle in a solution, which is probably due to the process of adhesion of fine particles of dispersed systems in larger under the influence of adhesion forces with the formation of coagulation structures

Summary

Introduction

In recent years magnetic resonance imaging (MRI) has become one of the leading research methods and its diagnostic capabilities continue to expand. A search for new contrast agents is intensively conducted [1,2,3,4,5]. Many of these materials are classified as nanoparticles. Interest in the use of nanoparticles in MRI imaging is caused by the high sorption capacity of materials due to the developed surface, so that nanoparticles can approach biological objects, interact and connect with them. The magnetic properties of the substance change significantly during the transition to the nanostructure, as a result of which nanomaterials get unusual ferro- and superparamagnetic properties

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