Abstract
The purpose of the present study was investigating the GC-MS analysis, preliminary phytochemical screening, physicochemical analysis and anti-diabetic activity of ethanol extract of the leaves of Jasminum cuspidatum. The anti-diabetic activity was investigated in streptozotocin-induced diabetes rats with treatment of ethanol extract at the dose level of 200 and 400 mg/kg, which was compared with glibenclamide at a dose level of 4 mg/kg and the parameter measured being the blood glucose, total cholesterol, HDL, LDL, VLDL, triglycerides, and total protein. An oral glucose tolerance test (OGTT) was also investigated in experimental rats. The GC-MS analysis revealed that the ethanol extract contained seven phytoconstituents. Preliminary phytochemical screening showed the presence of triterpenoids, flavonoids, glycosides and steroids. The result of in vivo anti-diabetic activity revealed that the ethanol extract of J. cuspidatum showed significant anti-diabetic activity.
Highlights
Jasminum cuspidatum is belonging to the family of the Oleaceae
The Gas chromatography-mass spectroscopy (GC-MS) analysis of phytoconstituents in the ethanol extract of the leaves of J. cuspidatum revealed the presence of seven phytoconstituents (Figure 1)
The identification of the phytoconstituents in the ethanol extract by GC-MS was confirmed based on the peak area, retention time, and molecular formula
Summary
Jasminum cuspidatum is belonging to the family of the Oleaceae. It’s normally called Urumikol in Malayalam, and Oosi Malli in Tamil. Tamil Nadu in all districts (Wealth of India, 2003). It’s rigid, dense shrub, stem hardly subscandent, glabrous. Simple, 4-6 cm long and 2-3 cm broad, lanceolate, ovate, acute, shining green, coriaceous, with reticulating nerves. Nerves from the base and from midrib, distinct below. The calyx teeth linear, rigid erect, 4-6 mm long. Lobes are 1.5-1.7 cm long, oblong, acute, shorter than the tube. Berry is 8 x 7 mm, ovoid, glabrous (Hentry et al, 1987)
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