Abstract
In the present days, medicinal plants receive great attention to the researchers in the field of pharmacology, due to the fact that most of the drug industries rely on natural products more especially medicinal plants for the production of new drugs. Some traditional medicines and their derived products were often made from crude plant extracts, which include a mixture of complex different phytochemical constituents. The chemical features of these constituents vary substantially among different species. Gas chromatography and Mass spectroscopy (GC-MS) method used for the analysis of the obtained extracts can be a remarkable tool for screening the quantity of some active principles in herbs used in pharmaceutical industries. The identification of secondary metabolites is based on the peak area, retention time-molecular weight, molecular formula, MS Fragment- ions and Pharmacological Actions. The aim of this study was to carry out for identification of bioactive compounds from the leaf ethyl acetate and methanolic extract of Artocarpus altilis by (GC-MS). Fifty and fifteen bioactive phytochemical compounds were identified in the methanolic and ethyl acetate extracts respectively. GC/MS analysis revealed the existence of Acetic acid, n-Hexadecanoic acid, 1,2,3-Propanetriol, 1-acetate (Acetin), Hexadecanoate , 7-Tetradecenal, in the methanol extract while the ethyl acetate extract revealed the presence of 3, 7-dimethyl-2, 6-octadienal (Geranial-pseudo phytol), 3,7,11,15Tetramethyl-2-hexadecen-1-ol (Phytol), Piperonal and Heliotropin. Further studies are needed to isolate active principle of the extract as well as to elucidate their exact mechanism of action in various disorders.
Highlights
The genus Artocarpus belongs to the family Moraceae which comprises about 60 genera and over 1000 species
Islanders use the latex of A. altilis to treat skin diseases, stomach ache, diarrhoea and dysentery [30]
The study was conducted in the rainforest of Kampung Peta located border to the north-east of Endau, Johor Darul Takzim and south to Rompin, Pahang
Summary
The genus Artocarpus belongs to the family Moraceae which comprises about 60 genera and over 1000 species. Many of these species are used as a source of food and in traditional medicinal practices [14]. The important species belonging to this genus are A. heterophyllus, A. altilis, A. hirsutus, A. lakoocha and A. camansi. The plant latex has significant contribution in medicine as it contains biologically active compounds such as alkaloids, flavonoids, terpenoids, glycosides, phenolics, tannins and saponins etc. Islanders use the latex of A. altilis to treat skin diseases, stomach ache, diarrhoea and dysentery [30]. Crushed leaves are used to treat skin, ear and eye infections. Other medicinal uses include the roots as stringent, purgative and poultice for skin ailments, and the bark for treating headache
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