Abstract
Exercise performance is influenced by genetics. However, there is a lack of knowledge about the role played by genetic variability in the frequency of physical exercise practice. The objective was to identify genetic variants that modulate the commitment of people to perform physical exercise and to detect those subjects with a lower frequency practice. A total of 451 subjects were genotyped for 64 genetic variants related to inflammation, circadian rhythms, vascular function as well as energy, lipid and carbohydrate metabolism. Physical exercise frequency question and a Minnesota Leisure Time Physical Activity Questionnaire (MLTPAQ) were used to qualitatively and quantitatively measure the average amount of physical exercise. Dietary intake and energy expenditure due to physical activity were also studied. Differences between genotypes were analyzed using linear and logistic models adjusted for Bonferroni. A significant association between GCKR rs780094 and the times the individuals performed physical exercise was observed (p = 0.004). The carriers of the minor allele showed a greater frequency of physical exercise in comparison to the major homozygous genotype carriers (OR: 1.86, 95% CI: 1.36–2.56). The analysis of the GCKR rs780094 variant suggests a possible association with the subjects that present lower frequency of physical exercise. Nevertheless, future studies are needed to confirm these findings.
Highlights
Physical exercise and energy intake are fundamental factors in the energy balance equation and in body weight management [1]
Knowledge about the factors associated with physical activity practice and energy expenditure as well as the potential mechanisms involved in fuel homeostasis is essential in order to understand human thermodynamics [1]
Women had higher total cholesterol and high-density lipoprotein (HDL) cholesterol levels while triglycerides/glucose index, Total Cholesterol/HDL and low-density lipoprotein cholesterol (LDL)/HDL were of lower values
Summary
Physical exercise and energy intake are fundamental factors in the energy balance equation and in body weight management [1]. The energy used during physical performance is the most variable component of total energy expenditure [2]. This feature depends on different factors such as body composition, intensity and duration of the physical activity, and the individual genetic profile [3,4]. There is a lack of research about the role that genetic variability plays in the motivation for practicing any physical exercise, the adherence to it and the related efficiency
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