Abstract
The aim of this study was to verify the potential of Mangifera indica gum (MIG) as a bioactive agent. Plant gum was collected from the bark of Mangifera indica and was, purified and characterized with Fourier-transform infrared spectroscopy and gas chromatography (GC) analyses. Purified gum was tested for its antimicrobial, antioxidant, antidiabetic, and anti-inflammatory. IR and GC analyses of gum showed the presence of several types of bioactive components in Mangifera indica gum. The gum showed potent antibacterial activity against Gram-positive bacteria Staphylococcus aureus (63%) and Enterococcus faecalis (58%). The antioxidant activity of MOG was investigated by 2,2- diphenyl 2- picryl hydrazyl hydrate (DPPH) radical scavenging and the MIG shows good activity when compared with the standard ascorbic acid. The anti-inflammatory activity of the MIG was estimated by the bovine serum albumin denaturation (BSA)method and showed significant activity against the standard drug. The anti-diabetic activity of the MIG was determined by the dinitro salicylic acid (DNSA)method displayed significant anti-diabetic activity. These findings confirmed that MIG has a potential source for the formulation of new therapeutic drugs.
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