Abstract
The transient receptor potential vanilloid 5 (TRPV5) channel belongs to the transient receptor potential (TRP) channel family. While other members of the six subfamilies (TRPV, TRPC, TRPM, TRPA, TRPP, and TRPML) are mainly non-selective cation channels, two members of the TRPV subfamily (TRPV5 and TRPV6) are highly Ca2+ selective. TRPV5 and is primarily expressed on the apical membrane of the distal convoluted tubule in the kidney and plays an important role in systemic Ca2+ homeostasis. One important regulator of TRPV5 found in multiple studies is protein kinase A (PKA), which activates the channel by phosphorylating T709.
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