Abstract
Asymmetrical displacement currents in the Ranvier node membrane ofRana ridibunda, treated with tetrodotoxin and tetraethylammonium, were studied by the use of ramp voltage pulses. In some experiments both ramp- and step-voltage pulses were used. The net displacement current is the sum of two components, one of which can be blocked by the local anesthetic trimecaine or inactivated by a preliminary 10-msec depolarizing pulse of sufficient amplitude to in activate sodium currents in the control solution. The parameters of distribution of the charge carrying the inactivated part of the displacement current are close to (although not identical with) the parameters of the sodium conductivity versus membrane potential curve. The inactivated charge is 30–50% of the total displaced charge. It is suggested that the inactivation- and trimecaine-sensitive components of the displacement current may be the true gating current.
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