Abstract
The concept of electromechanical coupling between voltage sensor (VS) activation and pore opening is firmly established for tetrameric voltage-gated cation channels (VGCs). Coupling of VS activation to opening of the intrinsic ‘aqueous’ H+ conductance (GAQ) in Hv1 channels is not well understood, in part because of technical difficulties inherent to measuring gating current in isolation from GAQ-mediated ionic current and achieving sufficiently high protein expression. Here we show that a combination of point mutations simultaneously accelerates activation kinetics and blocks outward current carried by GAQ.
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