Gated SPECT in assessment of regional and global left ventricular function: Major tool of modern nuclear imaging

Abstract

We have reviewed the development of assessments of ventricular function by use of gated MPS and the ways in which these measurements have contributed to the emergence of gated SPECT with regard to its important role as a major tool of modern cardiac imaging. We conclude that gated MPS imaging has shown a unique capability to provide precise, reproducible, and operator-independent quantitative data regarding myocardial perfusion, global and regional systolic and diastolic function, stress-induced RWMAs, ancillary markers of severe and extensive disease, LV geometry and mass, and finally, the presence of scars and viability. Adding functional data to perfusion provides highly effective means of increasing both diagnostic accuracy and reader confidence in the interpretation of the results of perfusion scans. Assessment of global and regional LV function has improved the prognostic power of the MPS study, which has been shown to play a central role in guiding patient management decisions, particularly regarding the need for revascularization, even without function variables.