Abstract
Donald J. Cram, the great UCLA chemist, received the Nobel Prize for his discoveries about host-guest complexes [1]. Both theoretical and experimental studies have been conducted about the nature and strength of interactions between the host and guest molecules. The concepts of constrictive binding (the activation energy of the binding process) and intrinsic binding (the free energy difference between the complex and the free host and guest molecules) were introduced to characterize different binding properties (Figure 1) [2].
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