Abstract
GATA transcription factors are zinc finger DNA binding proteins that activate transcription during development and cell differentiation. To date, 7 members of GATA family have been reported. However, the expression patterns and the exact roles of distinct GATA family members contributing to tumorigenesis and progression of breast cancer (BC) remain to be elucidated. Here, we studied the expression of GATA transcripts in a variety of tumor types compared with the normal controls using the ONCOMINE and GOBO databases, along with their corresponding expression profiles in an array of cancer cell lines through CCLE analysis. Based on Kaplan-Meier plotter, we further investigated the prognostic values of GATA members specifically high expressed in BC patients. It was found that, when compared with normal tissues, GATA3 and TRPS1 were distinctly high expressed in BC patients among all GATA members. GATA3 expression was significantly associated with ESR1, while TRPS1 was correlated with ERBB2. In survival analysis, GATA3 and TRPS1 mRNA high expressions were correlated to better survival in BC patients, and TRPS1 high expression was significantly associated with longer RFS in patients who have received chemotherapy. These results suggest that GATA3 and TRPS1 are distinct biomarkers and essential prognostic factors for breast cancer.
Highlights
Breast cancer (BC) remains the top cancer and the principle cause of death from cancer in women worldwide [1]
GATA3 and TRPS1 mRNA high expressions were correlated to better survival in BC patients, and TRPS1 high expression was significantly associated with longer RFS in patients who have received chemotherapy
These results suggest that GATA3 and TRPS1 are distinct biomarkers and essential prognostic factors for breast cancer
Summary
Breast cancer (BC) remains the top cancer and the principle cause of death from cancer in women worldwide [1]. Disorder in development of mammary epithelia is a prominent process contributing to tumorigenesis of BC [2]. GATA has been identified as one of the transcription factors that play an essential role during epithelial proliferation [6,7,8], which comprised family members sharing highly conserved zinc fingers that recognize the motif WGATAR to mediate DNA binding and protein interactions [9]. GATA1 and GATA2 play pivotal roles in regulating cell cycle or proliferation [13]. GATA3 is estimated to be the most abundant transcription factor in luminal epithelial cells expression and is required for normal development of the mammary gland [14, 15]
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