Gastroretentive drug delivery system of levofloxacin hemihydrate

Abstract

The aim of the studies to formulate and develop mucoadhesive microcapsules of levofloxacin hemihydrates by using the mucoadhesive polymers for the treatment of H. pylori infection. Methods: Microspheres were prepared by Ionotropic gelation technique. To achieve the mucoadhesive and extended release property in this study, sodium alginate, chitosan and calcium chloride for formulating levofloxacin hemihydrate microcapsules. In vitro drug release and in-vitro mucoadhesiveness. Results: To achieve the mucoadhesive and extended release property in this study, mucoadhesive polymer, such as chitosan was used. Sodium dioctyl sulphosuccinate (DOSS) used as surfactant. The percentage yield for levofloxacin hemihydrate loaded microspheres was found to be in the range of 32.11±1.25% to 87.28±1.67%. Drug content of the levofloxacin hemihydrate loaded microspheres varied from 20.21±1.01% to 30.77±1.88%. The encapsulation efficiency of the prepared microspheres varied from 51.77±1.33% to 78.54±1.55%. The mean diameter of levofloxacin hemihydrate loaded microspheres were found to be in the range of 135.5±3.64 μm to 448.59±5.44μm Mucoadhesive property of the prepared microspheres varied from 45.81±1.32% to 82.97±0.82%. A significant decrease in the rate and extent of drug release was observed with the increase in sodium alginate concentration in beads.