Abstract
Inulae Flos, the flower of Inula britannica L., is used as a dietary supplement, beverage, and medicine in East Asia. In this study, we evaluated the gastroprotective effects of Inulae Flos extract (IFE) against gastric mucosal lesions induced by hydrochloric acid (HCl)/ethanol in rats and explored its potential mechanisms by measuring antioxidant enzyme activity, mucus secretion, and prostaglandin E2 (PGE2) levels. Pretreatment with IFE at doses of 100 and 300 mg/kg significantly inhibited gastric lesions in HCl/ethanol-treated rats. IFE increased the activities of superoxide dismutase and catalase and the levels of glutathione and PGE2 in gastric tissues. The administration of IFE also significantly increased the gastric wall mucus contents in HCl/ethanol-induced gastric lesions. These findings suggest that IFE has gastroprotective effects against HCl/ethanol-induced gastric lesions and exerts these effects through increased antioxidant levels and gastric mucus secretion. Inulae Flos may be a promising agent for the prevention and treatment of gastritis and gastric ulcers.
Highlights
As a common type of upper gastrointestinal disorder, gastric ulcers are induced by an imbalance between aggressive factors (such as hydrochloric acid (HCl) and pepsin secretion) and protective factors [1].The onset of gastric ulcers is related to genetic factors and environmental factors, such as unhealthy lifestyle and Helicobacter pylori infection [2].The incidence of gastric ulcers is 0.1–0.3%/year, and, in the general population, the lifetime prevalence of this disease is 10% [3]
These findings suggest that Inulae Flos extract (IFE) has gastroprotective effects against HCl/ethanol-induced gastric lesions and exerts these effects through increased antioxidant levels and gastric mucus secretion
Inulae Flos may be a promising agent for the prevention and treatment of gastritis and gastric ulcers
Summary
As a common type of upper gastrointestinal disorder, gastric ulcers are induced by an imbalance between aggressive factors (such as hydrochloric acid (HCl) and pepsin secretion) and protective factors (such as prostaglandins, mucus production, antioxidants, and adequate blood flow) [1].The onset of gastric ulcers is related to genetic factors and environmental factors, such as unhealthy lifestyle (such as excessive alcohol consumption, smoking, and excessive salt intake) and Helicobacter pylori infection [2].The incidence of gastric ulcers is 0.1–0.3%/year, and, in the general population, the lifetime prevalence of this disease is 10% [3]. As a common type of upper gastrointestinal disorder, gastric ulcers are induced by an imbalance between aggressive factors (such as hydrochloric acid (HCl) and pepsin secretion) and protective factors (such as prostaglandins, mucus production, antioxidants, and adequate blood flow) [1]. The onset of gastric ulcers is related to genetic factors and environmental factors, such as unhealthy lifestyle (such as excessive alcohol consumption, smoking, and excessive salt intake) and Helicobacter pylori infection [2]. The incidence of gastric ulcers is 0.1–0.3%/year, and, in the general population, the lifetime prevalence of this disease is 10% [3]. The incidence of gastric ulcers has continued to decline, these ulcers still result in various complications and even death [4]. Antibiotics, H2 receptor antagonists, proton pump inhibitors, and antacids have been used to treat gastric ulcers. Recent studies have identified various natural products as potentially safe alternatives with few side effects [8,9,10]
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