Gastroprotective Effect of Zingerone on Ethanol-Induced Gastric Ulcers in Rats.

Neda Sistani Karampour,Fatemeh Kordi,Ardeshir Arzi,Anahita Rezaie,Marzieh Pashmforoosh

doi:10.3390/medicina55030064

Neda Sistani Karampour, Fatemeh Kordi + Show 3 more

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https://doi.org/10.3390/medicina55030064

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Abstract

Background and objectives: Zingerone is an ingredient of ginger (Zingiber officinale) with different pharmacological activities. Several studies have investigated the effect of zingerone on various gastrointestinal diseases, including irritable bowel syndrome and diarrhea. This study is aimed to evaluate the effect of zingerone on ethanol-induced gastric ulcers in rats. Materials and Methods: Gastric ulcers were induced by ethanol (96%, 5 mL/kg, po) in male wistar rats and zingerone (50, 100, and 200 mg/kg) was administrated orally. Normal saline and ranitidine were used as negative and positive control, respectively. In this study, the number and length of ulcers, and malondialdehyde (MDA) and nitric oxide (NO) levels in stomach tissues were determined. Results: The findings showed that the mean number and length of gastric ulcers were significantly lower in zingerone-received groups than ethanol group (P < 0.05). The level of malondialdehyde was decreased in the stomach of zingerone groups (P < 0.05) compared to the ethanol group. In addition, zingerone treatment prevented the decrease of nitric oxide level by ethanol in the stomach tissue. Conclusions: The present study showed that zingerone has a protective effect on the ethanol-induced gastric ulcer, which may be due to its free radical scavenging activity.

Highlights

The peptic ulcer has been considered as one of the most common digestive diseases in the present century [1]
This study demonstrates that administration of zingerone at the doses of 100 and 200 mg/kg decreases the lipid peroxidation in the stomach and attenuates the ethanol-induced gastric ulcer in the rat
The present study showed that zingerone at doses 50, 100, or 200 mg/kg reduced the histopathologic changes and the number and size of gastric ulcers induced by ethanol in the rat

Summary

Introduction

The peptic ulcer has been considered as one of the most common digestive diseases in the present century [1]. In the United States, the risk of developing peptic ulcer disease is 10% over a lifetime. The pathophysiology of this disease has a multifactorial process that is caused by the imbalance between aggressive factors, in particular, acid and pepsin on one hand, and mucosal defense factors, especially blood flow and prostaglandins, on the other [3]. This study is aimed to evaluate the effect of zingerone on ethanol-induced gastric ulcers in rats. The number and length of ulcers, and malondialdehyde (MDA) and nitric oxide (NO) levels in stomach tissues were determined. Conclusions: The present study showed that zingerone has a protective effect on the ethanol-induced gastric ulcer, which may be due to its free radical scavenging activity

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Conclusion