Abstract
BackgroundSipjeondaebo-tang, a traditional herbal medicine, has been reported to activate the immune response. Although, most research has focused on its anticancer activity. The purpose of this study was to determine whether Sipjeondaebo-tang exerts antioxidant activity against ethanol-induced gastric injury.MethodsGastric mucosal injury was induced by the oral administration of absolute ethanol at 5 mL/kg to rats after 18 h fast. Sipjeondaebo-tang water extract (SDTW; 200 mg/kg of body weight) was administered to rats 2 h before the oral administration of absolute ethanol. Gastric mucosal injury was evaluated by measuring the gastric injury, such as extent of lesions, malondialdehyde (MDA) concentration, glutathione (GSH) content and activities of antioxidant enzymes including catalase, glutathione peroxidase, glutathione S-transferase, glutathione reductase, and superoxide dismutase in stomach tissue.ResultsOral administration of SDTW markedly decreased the damage by conditioning the gastric mucosa such as hemorrhage, hyperemia. Pretreatment with SDTW significantly reduced MDA concentration and significantly increased GSH content and the activities of antioxidant enzymes. In an acute toxicity study, no adverse effects of SDTW were observed at doses up to 5000 mg/kg/day.ConclusionsSDTW may protect the gastric mucosa against ethanol-induced gastric mucosa injury. These results suggested that SDTW might also play an important role in the gastroprotection based on their antioxidant effect.
Highlights
Sipjeondaebo-tang, a traditional herbal medicine, has been reported to activate the immune response
If the analysis of variance (ANOVA) showed a significant difference between groups, the data were analyzed further with a multiple-comparison procedure using Dunnett’s test [16]
Effect of Sipjeondaebo-tang water extract (SDTW) on gastric injury in rats Gastric mucosal injury was induced by oral administration of absolute ethanol
Summary
Sipjeondaebo-tang, a traditional herbal medicine, has been reported to activate the immune response. The purpose of this study was to determine whether Sipjeondaebo-tang exerts antioxidant activity against ethanol-induced gastric injury. Previous study has demonstrated that ethanol-induced gastric lesions are closely related to Herbal medicines are used as a supplemental therapy for many kinds of diseases by enhancing the immune responses. Sipjeondaebo-tang (Shi-Quan-Da-Bu-Tang in Chinese, Juzen-taiho-to in Japanese) comprises 10 different crude components obtained from natural herbs It is commonly prescribed for the treatment of a depressed or weakened state including fatigue, anemia and anorexia associated with various diseases [5,6]. Its antioxidant effect has not been studied sufficiently, and there are no reports about whether Sipjeondaebo-tang water extract (SDTW) can prevent ethanol-induced gastric injury. The present study was done to evaluate the antioxidant activities of SDTW against ethanol-induced gastric injury in rats
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
