Gastroprotective effect of fluvoxamine and ondansetron on stress-induced gastric ulcers in mice.

Abstract

The association between stress and gastric ulcers has been well reported. This study is divided into two parts: the first part of this study is consisted of analyzing the effect of fluvoxamine administration by intracerebroventricular (ICV) and intraperitoneal (IP) injections on stress-induced gastric ulcers. The second part investigates the effect of ondansetron in influencing the protection of the gastric mucous by giving fluvoxamine to the mice before being induced with stress. Water immersion restraint stress (WIRS) was used to induce stress. Fluvoxamine 50 and 100mg/kg by IP injection, fluvoxamine 9.3µg, and 18.6µg by ICV injection 30min before the induction of stress. Meanwhile, single drug and in combination administered to the mice, ondansetron 3mg/kg was given by IP at 60min, and fluvoxamine 50, 100mg/kg orally at 30min before stress induction. The obtained results show fluvoxamine 50 and 100mg/kg by IP, and fluvoxamine 18.6µg by ICV had significantly reduced ulcer index with p<0.005, p<0.001, and p<0.005 while fluvoxamine 9.3µg showed the insignificant result. Fluvoxamine 50mg/kg, fluvoxamine 100mg/kg, and ondansetron 3mg/kg monotherapy have a significant reduction in ulcers with p<0.005, p<0.001, and p<0.05, while the combination drugs showed an insignificant reduction in ulcers. Fluvoxamine with different administration routes and ondansetron monotherapy before stress reduce the occurrence of gastric ulcers, while the combination drugs did not increase the protective effect of the gastric mucosa.