Abstract
Background: Peptic ulcer disease remains endemic in our society affecting about four million people every year worldwide. Hannoa klaineana is used traditionally in the treatment of various gastrointestinal diseases including ulcer.Aim: This study aims at evaluating the gastroprotective effect of ethylacetate fraction of the leaves of Hannoa klaineana (Simaroubaceae).Methods: The gastroprotective effect of ethylacetate fraction of the Hannoa klaineana (50, 100 and 200mg/kg b.wt) was evaluated using aspirin and histamine induced ulcer models.Results: In aspirin-induced ulcer model, the ethylacetate fraction of the Hannoa klaineana demonstrated significant (p<0.001) decreased in mean ulcer index with the maximum protective effect (99.84%) at 200 mg/kg against the gastric damages. While histamine-induced ulcer model, the solvent fraction significantly (p<0.001) decreased mean ulcer index with the protective effect up to 99.83% against the gastric lesions. In both models, a significant (p<0.001) increased in pH value coupled with significant (p<0.001) decreased in gastric volume, free and total acidity in rats pre-treated with varying doses of the ethylacetate fraction was found.Conclusion: The mechanism of gastroprotective effects of ethylacetate fraction of the Hannoa klaineana could be attributed to its ability to stimulate prostaglandins secretion or possess prostaglandins like-substances or suppression of histamine-induced vasospastic effect and gastric secretion.  Â
Highlights
Ulcer is a gasto-intestinal disease characterized by disruption of mucosal integrity of the stomach, duodenum or lower esophagos (Kumar et al, 2011)
This study aims at evaluating the gastro-protective effect of the ethylacetate fraction of the leaves of Hannoa klaineana (Simaroubaceae) and to elucidate its mechanism of action in different ulcer models
The gastric mucosa of the rats pre-treated with 50 mg/kg dose of the solvent fraction showed spot ulcer (Fig.1D)
Summary
Ulcer is a gasto-intestinal disease characterized by disruption of mucosal integrity of the stomach, duodenum or lower esophagos (Kumar et al, 2011). Pylori infection and the therapeutical use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin (Goroll and Mulley, 2009; Zhang et al, 2014; Feldman et al, 2016) Ulcers and their complications can be caused by excessive alcohol consumption, smoking, diets (spicy food), emotional and psychosocial stress, genetic factors, ingestion of poisonous and other harmful substances and certain diseases (Andrade et al, 1988; Devi et al, 2011; Feldman et al, 2016). This study aims at evaluating the gastro-protective effect of the ethylacetate fraction of the leaves of Hannoa klaineana (Simaroubaceae) and to elucidate its mechanism of action in different ulcer models. Results: In aspirin-induced ulcer model, the ethylacetate fraction of the Hannoa klaineana demonstrated significant (p
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