Abstract
To investigate the gastroprotective effect of methanol extract of E. spectabilis and its major component isoorientin. Effects of isoorientin and methanol extract of E. spectabilis were investigated in indomethacin-induced gastric damage model on rats. Famotidine was used as the standard antiulcer drug. Numerical density of ulcer areas and oxidative status were determined on stomach tissues of rats. All doses of isoorientin and methanol extract decreased MDA level and increased SOD activity and GSH levels in the stomach tissue of rats. When numerical density of ulcer areas were analized, the 500 mg/kg dose of methanol extract (84%) exhibited a similar effect to 20 mg/kg dose of standart drug famotidine (87%). The gastroprotective effects of E. spectabilis and its major constituent isoorientin in rats for the first time. Detailed analyses suggested that potential antioxidant activity of both plant extract and isoorientin mediates the gastroprotective effect.
Highlights
The peptic ulcer is a deterioration in the gastric or duodenal mucosa down to the submucosa
The reactive oxygen species (ROS) play an important role in the gastric ulcer formation induced by stress, ethanol and nonsteroidal anti-inflammatory drugs (NSAIDs)
The most effective decline was observed at the 500 mg/kg dose of methanol extract dose
Summary
The peptic ulcer is a deterioration in the gastric or duodenal mucosa down to the submucosa. The various causes of gastric ulcer are stress, trauma, some diseases, helicobacter pylori, use of alcohol and cigarettes, and steroidal and nonsteroidal anti-inflammatory drugs (NSAIDs). The reactive oxygen species (ROS) play an important role in the gastric ulcer formation induced by stress, ethanol and NSAIDs. The inflammation in the gastric tissue induced by indomethacin causes the formation of ROS4. Superoxide dismutase, catalase, glutathione reductase, β-carotene, glutathione peroxidase, β-tocopherol, glutathione, vitamins A and C are good antioxidant agents. These antioxidants are effective in prevention stomach damage[5]
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