Gastroprotective Activity and Potential Mechanism of the Stem Bark of <i>Boswellia dalzielii</i> on Gastric Ulcer in Rat

Abstract

Gastric ulcer (GU) is the most common health concern that occurs due to alcohol consumption, smoking and physiological stress<i>. Boswelia dalzielii</i> (BD) is traditionally used to treat many diseases including gastric ulcers. This study aims to investigate the gastroprotective activity of <i>Boswelia dalzielii</i>. The cytoprotective property of <i>Boswelia dalzielii</i> was evaluated by using five experimental methods of GU: 1. Absolute ethanol, 2. HCl/Ethanol, 3. HCl/ Ethanol/ Indomethacin, 4. Indomethacin, 5. Pylorus ligation. Omeprazole was used as reference anti-ulcer drugs. Phytochemical screening of <i>Boswelia dalzielii</i> was carried out, and experimental Wistar rats (150-200 g) were used to evaluate the anti-ulcerogenic effects of the extract was carried out. Phytochemical screening of the effects of extract of <i>Boswelia dalzielii</i> extract revealed the presence of phytochemicals components such as tannins, saponins, flavonoids, triterpenes, and phenols. The oral administrations of 400 mg/kg of body weight of <i>Boswelia dalzielii</i> could protect the gastric mucosa against gastric ulcer. The results showed that <i>Boswelia dalzielii</i> at a concentration of 400 mg/kg has significant antiulcerogenic effects against absolute ethanol, hydrochloride ethanol (HCl/EtOH), HCl/ EtOH/IND, and pyloric ligation-induced gastric ulcer.