Abstract
BackgroundWith the recent increased use of lanthanum carbonate, several cases of lanthanum phosphate deposition to gastric mucosa in dialysis patients have been reported. However, the endoscopic appearance of the early-stage lesion and the over-time alterations of endoscopic findings due to the progression of lanthanum phosphate deposition remain unclear.Case presentationAn 80-year-old man receiving dialysis and taking lanthanum carbonate as a phosphate binder over a 4-year period underwent upper gastrointestinal endoscopy four times beginning 1 year after initiation of treatment. The first endoscopic examination (after 1 year of exposure to lanthanum carbonate) revealed rough mucosa with a few areas of white granular mucosa. Over the 3 years of endoscopic follow-up, the white granular mucosa spread and multiple erosions appeared. Histopathological findings of biopsy specimens from an erosion showed extensive infiltration by histiocytes containing deposits. Scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDX) revealed that the presence of the deposits containing phosphorus and lanthanum in the gastric mucosa.On the basis of these results, the patient was diagnosed with gastropathy associated with lanthanum phosphate deposition.ConclusionsOver a 3-year period, endoscopic findings associated with lanthanum deposition gradually changed and expanded from the early stage.
Highlights
With the recent increased use of lanthanum carbonate, several cases of lanthanum phosphate deposition to gastric mucosa in dialysis patients have been reported
Over a 3-year period, endoscopic findings associated with lanthanum deposition gradually changed and expanded from the early stage
Various endoscopic findings, such as white granular mucosa, ulcers, and erosion, are associated with lanthanum deposition; there have been no reports of changes over time in endoscopic findings in a single case from the onset of these changes
Summary
With the recent increased use of lanthanum carbonate, several cases of lanthanum phosphate deposition to gastric mucosa in dialysis patients have been reported. Conclusions: Over a 3-year period, endoscopic findings associated with lanthanum deposition gradually changed and expanded from the early stage. * Correspondence: thisamatsu@ks.kyorin-u.ac.jp 1Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, Tokyo 181-8611, Japan Full list of author information is available at the end of the article
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
