Abstract

aPTT may be falsely elevated and may lead to insufficient anticoagulation if dosing UFH from aPTT levels. This is a preliminary report in a small number of patients. However, the incidence of thrombosis is high in LVAD patients and all potential causes need to be reported quickly so that they can be investigated in larger numbers and at multiple institutions. Several hypotheses need to be tested in LVAD patients, including: exclusive monitoring of anti-Xa levels (or a combination of anti-Xa and aPTT) and the increased risk of bleeding when monitoring anti-Xa levels. Our results suggest that aPTT levels underestimate anti-coagulation in LVAD patients and monitoring UFH with anti-Xa levels more accurately reflects the level of anti-coagulation.

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