Gastropanel: A useful screening test in paediatric populations

Abstract

s / Digestive and Liver Dis for CMV in serum was negative. He was treated with proton pump inhibitor once a day and his condition gradually improved with complete histological recovery after 3 months. Conclusions. The case is described owing to the rarity of this disease in the international literature. The course of this pathology in childhood is typically benign and brief. May be important to establish the diagnosis of CMV infection in cases of suspect paediatric Menetrier’s disease. doi:10.1016/j.dld.2006.07.041 PP 13 GASTROPANEL: A USEFUL SCREENING TEST IN PAEDIATRIC POPULATIONS Graziella Guariso, Daniela Basso, Silvia Conte, Michela Fasolo, Adriano Tasinato, Filippo Navaglia, Paola Fogar, Carlo-Federico Zambon, Eliana Greco, Stefania Schiavon, Mario Plebani Universita degli Studi di Padova, Pediatria, Padua, Italy Objective. Ascertain the role of gastropanel (GP) in screening children for gastric inflammation. Methods.One hundred and ninety-five children (101 F, 94 M; mean age 7 years) underwent EGDS for chronic abdominal pain. During endoscopy, 105 had no evident lesions, 43 antral erythema, 15 diffuse gastritis, 4 duodenitis, 11 oesophagitis, 10 micronodular gastritis, and 7 had mosaic duodenal mucosa.Helicobacter pyloriwas histologically diagnosed in 17.6% of cases. In fasting sera pepsinogen A (PGA), pepsinogen C (PGC), gastrin-17 (G17), anti-H. pylori Ab were assayed and analysed by the GastroSoft for Excel (Biohit®, Helsinki, Finland). Results. 108/195 children had a histologically normal mucosa; 68 had gastric inflammation and 19 had extra-gastric lesions. PGC and anti-H. pylori were significantly correlated with H. pylori infection (t= 4.22, p< 0.001 and t= 5.28, p< 0.001). The GastroSoft provided five categories: normal, antral gastritis, antral atrophy, antral + body atrophy, body atrophy. GP sensitivity in identifying children with gastric inflammation was 29.4%, the specificity towards extra-gastric diseases was 68.4% while that towards controls was 95.4% (PPV 83.9%; PNV 70.7%). None of the single parameters discriminated gastric inflammation (under ROC curves areas: 0.60 for PGA, 0.63 for PGC, 0.57 for G-17, 0.72 for anti-H. pylori). Six of seven children with mosaic duodenal mucosa were biochemically classified as having corpus atrophy: two had autoimmune gastritis and four coeliac disease. Conclusion. GP might be a useful non invasive test for screening gastric inflammation in children. This test seems able to indicate also in children the presence of corpus atrophy which has probably to be histologically searched especially in subjects with coeliac disease. doi:10.1016/j.dld.2006.07.042 PP 14 CASEREPORT:ACERVICALOESOPHAGEALTIGHTSTENOSIS IN A PATIENT WITH AUTOIMMUNE POLIENDOCRINOPATHY TYPE 2 F. Fornaroli, B. Bizzarri, G. Biasucci, L. D’Amato, V. Corroppolo, A. Ghiselli, G. Carolla, G.L. de’ Angelis U.O.S. Gastroenterologia Pediatrica, Neonatologia e puericoltura, Parma,