Gastrointestinal stromal tumors (GISTs) - IHC study and correlation of CD-117 and PDGFR-α staining intensity with histomorphological features - A study of 8 cases

Abstract

Gastrointestinal Stromal Tumors (GISTs) are rare and constitute only 1% of all malignant tumors of the Gl Tract but are the most common mesenchymal neoplasm of the Gl tract. GISTS are typically defined by the expression of C-KIT (CD-I 17) in the tumor cells. Here we report a total number of 8 cases of GISTs studied by Immuno histochemical markers. Panel of IHC markers used are CD-117, PDGFR-a,S- 100, Desmin, CD-34, SMA and Epithelial Keratins. CD-117 and PDGFR-a staining intensity correlated with histomorphological features. Risk of progressive disease assessed based on histomorphological features and location of the tumor.