Abstract
Background: Gastrointestinal stromal tumors (GISTs) quite often co-exist with other primary tumors, as seen in up to 33% of cases. In the literature such occurrences have primarily been described through case reports and rarely through case series, which is not sufficient to prove if there is an association between these two entities.Materials and Methods: We conducted a retrospective study using medical and pathological records from sixty-nine patients who underwent surgical treatment for GIST in a single university surgical department between 2011 and 2019. Seven cases of GIST accompanying a synchronous primary tumor were identified and included in the study.Results: Survival analysis comparing the overall survival of patients with single GIST versus patients with concurrent GIST and another primary tumor, has shown no statistically significant difference between these two groups (p = 0.19). However, when comparing the recurrence rate, patients with synchronous GISTs and another primary tumor have a statistically significant increased possibility for recurrence (p = 0.02). Statistical analysis comparing the size of GISTs between the two groups has shown that patients with single GIST have larger tumors than patients with synchronous tumors (p = 0.048).Conclusions: The synchronous occurrence of GISTs and other intra-abdominal tumors is more common than previously considered, though it is not yet clear if there is a causal association for the concomitant occurrence. Further studies are required to elucidate the genetic and molecular mechanisms of carcinogenesis and progression associating GIST and synchronous tumors.
Highlights
They are rare neoplasms, gastrointestinal stromal tumors (GISTs) represent the most common mesenchymal tumors of the gastrointestinal (GI) tract
The synchronous occurrence of Gastrointestinal stromal tumors (GISTs) and other intra-abdominal tumors is more common than previously considered, though it is not yet clear if there is a causal association for the concomitant occurrence
In 37 cases (53.6%) GISTs were located in the stomach and in 11 cases (15.9%) they were located in the small intestine, there were 5 cases (7.2%) where GISTs were located in the duodenum, 4 cases (5.8%) with GISTs in the colon and sigmoid, 3 cases (4.3%) with GISTs in the mesentery, 2 cases (2.9%) with GISTs in the pelvis, and in 7 cases (10.1%) GISTs were found in other locations
Summary
They are rare neoplasms, gastrointestinal stromal tumors (GISTs) represent the most common mesenchymal tumors of the gastrointestinal (GI) tract. They originate from the cells of Cajal, which are responsible for autonomous GI movement [1,2,3]. Gastrointestinal stromal tumors (GISTs) quite often co-exist with other primary tumors, as seen in up to 33% of cases. In the literature such occurrences have primarily been described through case reports and rarely through case series, which is not sufficient to prove if there is an association between these two entities
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