Abstract
Gastrointestinal stromal tumors (GISTs) are defined as specific CD117-(Kit, stem cell factor receptor) expressing tumors of the gastrointestinal (GI) tract. They are believed to originate from the interstitial pacemaker cells of Cajal (ICC) or their progenitor cells. In horses only a few cases of GISTs are described in the literature. In the present paper the macroscopical, histological, immunohistochemical, and ultrastructural features of an equine cecal GIST are described.
Highlights
Gastrointestinal stromal tumors (GISTs) are defined as specific CD117-(Kit, stem cell factor receptor) expressing tumors of the gastrointestinal (GI) tract
The embryonic isoform of smooth muscle myosin heavy chain is expressed in both GISTs and interstitial pacemaker cells of Cajal (ICC) what supports the origin from ICCs [13]
GIST development can be associated with gain-of-function mutations of c-kit, a protooncogene in humans that may lead to autophosphorylation, cellular proliferation, and reduction of apoptosis [17]
Summary
Case Report Gastrointestinal Stromal Tumor in the Cecum of a Horse Gastrointestinal stromal tumors (GISTs) are defined as specific CD117-(Kit, stem cell factor receptor) expressing tumors of the gastrointestinal (GI) tract. In horses only a few cases of GISTs are described in the literature.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
