Abstract

Triple immunosuppressive therapy after organ transplantation may cause several gastrointestinal disturbances and it is difficult to identify which drug causes more complications. The aim was to compare the gastrointestinal motility in immunosuppressed rats under three different immunosuppressants. Male rats were immunosuppressed by gavage during 14 days with Tacrolimus (n=7), Cyclosporine (n=9) and Prednisone (n=8). Animals received a magnetic pellet before (control) and after treatment to monitor gastrointestinal transit and contractility by AC Biosusceptometry (ACB). The following parameters were measured: serum creatinine, frequency and power of contraction, mean time of gastric emptying (MGET), mean time to reach cecum (MCAT) and mean transit time through small bowel (MSBTT). Data were analyzed by ANOVA (Student-Newman-Keuls) and Pearson correlation. Our data showed a low serum creatinine level and none difference among groups. Frequency and power of contractions were increased after treatment with cyclosporine (p<0.04 and p<0.025, respectively) and frequency enhanced after tacrolimus (p<0.04). Our results showed that MGET after prednisone, cyclosporine and tacrolimus were reduced compared to controls (p<0.04, p<0.05 and p<0.004, respectively). MSBTT was longer for tacrolimus and prednisone compared to controls (p<0.004 and p<0.004 respectively). Also, prednisone and tacrolimus presented a faster MGET (p<0.02 and p<0.04, respectively) compared to cyclosporine. During control there was a strong positive correlation (P=0.77) between MGET and frequency, while was inverse between MGET and power (P=-0.75), with complete absence of correlation after treatment. In summary, cyclosporine has less effect on transit and prednisone seems do not affect contractility; however all these drugs should be carefully prescribed to prevent gastrointestinal symptoms and improve quality of life after transplantation.

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