Abstract
Objective: to assess clinical and morphological characteristics and occurrence of micronuclei of mucocytes of the integumentary and epithelium of the gastric mucosa in residents of areas affected by Chernobyl nuclear accident taking into account Helicobacter pylori (Hp) infection and nutritional factors. Methods: a retrospective study was conducted using a micronuclear test in integumentary-pit epithelium to study cytogenetic effects of small doses of ionizing radiation. Results. Mucocytes with micronuclei were predominantly observed in persons permanently residing in radiation contaminated areas since 1986. The occurrence of micronucleation was not statistically associated with Hp infection. No associations were found for the total alpha and beta activity of biopsy specimens of the gastric mucosa and the density of contamination of the territory at 90Sr and 137Cs. Conclusions: Our findings suggest that gastrointestinal pathology in residents of the territories affected by Chernobyl accident seems to have multifactorial origin related not only to the nuclear accident in Chernobyl.
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